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Pexiganan (MSI 78 free base) is a synthetic analog of magainin 2. Pexiganan is a potent and orally active broad-spectrum antimicrobial peptide. Pexiganan can be used in the research of infections, such as diabetic foot ulcer infections[1].

Pexiganan is synthesized using a combination of liquid-phase and solid-phase methods. Step 1: The dipeptide fragment Fmoc-Lys(Boc)-Lys(Boc)-OH is synthesized via liquid-phase method. Specifically, Fmoc-Lys(Boc)-OH is activated with HOSu and DCC to form th

[1] Lamb HM, et al. Pexiganan acetate. Drugs. 1998 Dec;56(6):1047-52; discussion 1053-4. DOI:10.2165/00003495-199856060-00011
[2] Ge Y, et al. In vitro antibacterial properties of pexiganan, an analog of magainin. Antimicrob Agents Chemother. 1999 Apr;43(4):782-8. DOI:10.1128/AAC.43.4.782
[3] Zhang XL, et al. The synthetic antimicrobial peptide pexiganan and its nanoparticles (PNPs) exhibit the anti-helicobacter pylori activity in vitro and in vivo. Molecules. 2015 Mar 2;20(3):3972-85. DOI:10.3390/molecules20033972
[4] Giacometti A, et al. Effects of pexiganan alone and combined with betalactams in experimental endotoxic shock. Peptides. 2005 Feb;26(2):207-16. DOI:10.1016/j.peptides.2004.09.012