147600-40-6

Ac-Leu-Val-Lys-Aldehyde is a potent cathepsin B inhibitor with IC50s of 4 nM. Ac-Leu-Val-Lys-Aldehyde significantly reduces quinolinic acid (HY-100807)-induced striatal cell death and causes accumulation of LC3-II[1].

Cell permeable: no''Primary Target
cathepsin B''Product does not compete with ATP.''Reversible: no''Target IC50: 4 nM against cathepsin B

Cathepsin B: 4 nM (IC₅₀)

[1] McConnell RM, et al. Inhibition studies of some serine and thiol proteinases by new leupeptin analogues. J Med Chem. 1993 Apr 16;36(8):1084-9. DOI:10.1021/jm00060a016
[2] Wang YR, et al. Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons. PLoS One. 2013 Sep 20;8(9):e75702. DOI:10.1371/journal.pone.0075702