14756-26-4

BRD56491 is a nontoxic enhancer of reactive oxygen species (ROS) th at strongly elevates markers of oxidative stress without causing cell death. Howevercombining BRD56491 with nontoxic doses of the glutathione synthesis inhibitor L-buthionine sulfoximine did lead to cell death in a variety of cancer cell lines. BRD56491 can be used to create a more oxidizing cell state and aid in studies of cancer cell lines resilient to induced increases in ROS levels.