LY 288513 is a CCK-B antagonist, which blocks the effects of nicotine withdrawal on auditory startle.
Definition
ChEBI:(4S,5R)-N-(4-bromophenyl)-3-oxo-4,5-diphenyl-1-pyrazolidinecarboxamide is a stilbenoid.
Biological Activity
Selective CCK 2 receptor antagonist (IC 50 values are 16 and > 30,000 nM for CCK 2 and CCK 1 respectively). Displays anxiolytic and antipsychotic properties in vivo .
in vivo
LY288513 (3, 10 mg/kg, i.p.; 10, 30 mg/kg, p.o.) produces an anxiolytic-like action in mice[3].
LY288513 (1000 mg/kg, p.o.) potentiates the effects of a CNS depressant, slightly lowered body temperature, and had modest sedative effects only at the highest dose examined[3].
Animal Model:
Male CD-l mice[3]
Dosage:
3, 10 mg/kg; 10, 30 mg/kg
Administration:
I.p.; p.o.
Result:
Displayed anxiolytic-like effects in the elevated plusmaze.
