AS-183 is an inhibitor of cholesterol acyltransferase (ACAT) (IC50=0.94 μM). AS-183 also inhibits the formation of cholesterol esters in HepG2, CaCo2 and THP-1 cells with IC50 values ??of 18.1, 25.5 and 34.5 μM, respectively. AS-183 can be used in the study of atherosclerosis and hypercholesterolemia[1].
References
[1] Kuroda, et al. AS-183, a novel inhibitor of acyl-CoA: cholesterol acyltransferase produced by Scedosporium sp. SPC-15549. The Journal of Antibiotics 46.8 (1993): 1196-1202. DOI:10.7164/antibiotics.46.1196
