146731-14-8

Name	1H-Indene-5-acetic acid, 2-[[[(4-chlorophenyl)sulfonyl]amino]methyl]-2,3-dihydro-, sodium salt (1:1)
CAS	146731-14-8
Molecular Formula	C18H19ClNNaO4S
MDL Number	MFCD00941373
Molecular Weight	403.85
MOL File	146731-14-8.mol

Synonyms

Z-335 sodium 1H-Indene-5-acetic acid, 2-[[[(4-chlorophenyl)sulfonyl]amino]methyl]-2,3-dihydro-, sodium salt (1:1)

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Hazard Information

Description

Z-335 Salt is a thromboxane A2 receptor antagonist potentially for the treatment of arterial occlusive disease.

Uses

Z-335 sodium is an orally active thromboxane a2 (TXA2) receptor antagonist, with IC50 values of 29.9 nM and 32.5 nM for human and Guinea pig platelets, respectively[1][2].

in vivo

Z-335 (0.3-3 mg/kg, p.o.) inhibits thrombus formation in a dose-dependent manner^[2].
Z-335 (3 mg/kg, p.o.) significantly prevents thrombus formation even at 16 h ^[2].

References

[1] T Tanaka, et al. Antiplatelet effect of Z-335, a new orally active and long-lasting thromboxane receptor antagonist. Eur J Pharmacol. 1998 Sep 11;357(1):53-60. DOI:10.1016/s0014-2999(98)00540-8
[2] T Tanaka, et al. Z-335, a new thromboxane A(2) receptor antagonist, prevents arterial thrombosis induced by ferric chloride in rats. Eur J Pharmacol. 2000 Aug 11;401(3):413-8. DOI:10.1016/s0014-2999(00)00434-9

Supplier

Suzhou Meishi Biotechnology Co., Ltd.

Telephone 1173954148q

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1822805/0_EN.htm

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Wuhan Han Sheng New Material Technology Co.，Ltd

Telephone +86-17798174412

Websitehttps://www.hsnm.com.cn/

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