1466445-39-5

EGFR-IN-40 (compound 3z) is a potent BTK, EGFR, and ITK inhibitor with IC50 values of 1.2 nM, 5.3 nM, and 46.1 nM, respectively[1].

BTK: 1.2 nM (IC₅₀); EGFR: 5.3 nM (IC₅₀); ITK: 46.1 nM (IC₅₀)

[1] Dou Dou, et al. Discovery of Pteridine-7(8 H)-one Derivatives as Potent and Selective Inhibitors of Bruton's Tyrosine Kinase (BTK). J Med Chem. 2022 Feb 10;65(3):2694-2709. DOI:10.1021/acs.jmedchem.1c02208