146135-18-4

Name	CarbaMic acid, (1-Methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl)-, phenylMethyl ester (9CI)
CAS	146135-18-4
Molecular Formula	C25H21N5O2
MDL Number	MFCD19443120
Molecular Weight	423.47
MOL File	146135-18-4.mol

Synonyms

TUWDLUFFAHHNEF-UHFFFAOYSA-N Carbamic acid, N-(1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl)-, phenylmethyl ester CarbaMic acid, (1-Methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl)-, phenylMethyl ester (9CI)

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Hazard Information

Description

GW841819X is an analogue of (+)-JQ1 and a novel inhibitor of BET bromodomains. GW841819X displayed activity in vivo against NUT-midline carcinoma, multiple myeloma, mixed-lineage leukemia, and acute myeloid leukemia. Bromodomain and extra-terminal (BET) proteins belong to a class of proteins collectively called epigenetic "readers". BET bromodomains have emerged as promising drug targets for treatment of cancers, inflammatory diseases, and other medical conditions.

Uses

GW 841819X is a potent inducer of the ApoA1 report gene, with an EC170 of 0.22 μM, and its pIC50 for Brd2/3/4 is 5.9/6.2/6.3[1].

References

[1] Olivier Mirguet, et al. Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains. J Med Chem. 2013 Oct 10;56(19):7501-15. DOI:10.1021/jm401088k

Supplier

HANGZHOU CLAP TECHNOLOGY CO.,LTD

Telephone86-571-88216897,88216896 13588875226

Websitehttp://www.hzclap.com/en/

Nantong QuanYi Biotechnology Co., Ltd

Telephone0513-66337626 18051384581

Websitehttps://www.chemhifuture.com/

Nanjing Shizhou Biology Technology Co.,Ltd

Telephone025-85560043 15850508050

Websitehttp://www.synzest.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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