ChemicalBook CAS DataBase List 146062-44-4

146062-44-4

Name	Hydroxypioglitazone
CAS	146062-44-4
Molecular Formula	C19H20N2O4S
MDL Number	MFCD00916074
Molecular Weight	372.44
MOL File	146062-44-4.mol

Chemical Properties

Appearance	Off-White Solid
Melting point	157-1580C
Boiling point	627.6±55.0 °C(Predicted)
density	1.325±0.06 g/cm3(Predicted)
storage temp.	-20°C Freezer, Under Inert Atmosphere
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
form	Solid
pka	6.35±0.50(Predicted)
color	White to Off-White
Stability:	Hygroscopic
CAS DataBase Reference	146062-44-4

Hazard Information

Chemical Properties

Off-White Solid

Uses

A metabolite of Pioglitazone (P471000).

Description

Hydroxy pioglitazone is a major metabolite of the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone (Item Nos. 71745 | 22263 | 10028). It is formed from pioglitazone by the cytochrome P450 (CYP) isoform CYP2C8 with minor contributions from CYP3A4. Hydroxy pioglitazone binds to PPARγ (K_i = 1.2 μM) and activates PPARγ in a time-resolved FRET (TR-FRET) assay (EC₅₀ = 2.1 μM).

Definition

ChEBI: Hydroxypioglitazone is a member of the class of thiazolidenediones that is the hydroxy derivative of pioglitazone. It has a role as a human xenobiotic metabolite. It is a member of thiazolidinediones, a member of pyridines and an aromatic ether. It is functionally related to a pioglitazone.

in vivo

Leriglitazone (50 mg/kg; Feed administration; 8 months) improves motor impairment in a Friedreich ataxia mouse model^[2].
Leriglitazone (75 mg/kg; Feed administration; 7 months) has an improved effect in Rett mouse model^[3].

Animal Model:	YG8sR mice^[2]
Dosage:	50 mg/kg
Administration:	Feed administration; 8 months
Result:	Did not change the weight gain of YG8sR mice. Improved the performance of the YG8sR mice in the case of the balance beam test.

Animal Model:	Rett female mice^[3]
Dosage:	75 mg/kg
Administration:	Feed administration; 7 months
Result:	Corrected the defect of ATP concentration and lipid peroxidation in hippocampus and cerebellum. Reduce the level of 8-OHdG, ROS, MnSOD and GPX. Improved overall health and exploratory behavior in mice.

IC 50

PPAR-γ: 9 μM (EC₅₀)

storage

Store at -20°C

References

[1] SARAHA. MOSURE. Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPARγ Drug Pioglitazone[J]. Journal of Medicinal Chemistry, 2019, 62 4: 2008-2023. DOI: 10.1021/acs.jmedchem.8b01573
[2] TIINA JAAKKOLA. Effect of rifampicin on the pharmacokinetics of pioglitazone[J]. British journal of clinical pharmacology, 2005, 61 1: 70-78. DOI: 10.1111/j.1365-2125.2005.02515.x

Supplier

J & K SCIENTIFIC LTD.

Telephone18210857532; 18210857532

Websitehttps://www.jkchemical.com

3B Pharmachem (Wuhan) International Co.,Ltd.

Telephone 18930552037

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList13285/0_EN.htm

Chemsky（shanghai）International Co.,Ltd.

Telephone021-50135380

Websitehttp://www.shchemsky.com

Daicel Chiral Technologies (China)CO.,LTD

Telephone021-50460086-9 15921403865

Websitehttp://www.daicelchiraltech.cn/reagents/Default.aspx

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Telephone0755-4000505016 13380397412

Websitehttps://www.sincopharmachem.net

Cato Research Chemicals Inc.

Telephone020-81960175

Websitehttp://www.cato-chem.com

ShangHai Caerulum Pharma Discovery Co., Ltd.

Telephone18149758185 18149758185

Websitehttp://www.caerulumpharma.com

Quality Control Solutions Ltd.

Telephone0755-66853366 13670046396

Websitehttp://www.qcsrm.com

Finetech Industry Limited

Telephone027-87465837 19945049750

Websitehttps://www.finetechchem.com/

Alta Scientific Co., Ltd.

Telephone022-6537-8550 15522853686

Websitehttp://www.altascientific.cn

Artis Biotech Co. Ltd.

Telephone19138486554 18108108965

Websitehttps://artis-standards.com/

Hubei Yangxin Medical Technology Co., Ltd.

Telephone 15374522761

Websitehttps://www.standardpharm.org.cn/

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Telephone0755-28967200 13631290199

Websitehttps://sungenmed.com/

Shanghai Hongye Biotechnology Co. Ltd

Telephone400-9205774

Websitehttp://www.glpbio.cn/

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Telephone+86-400-002-6226 +86-13028896684;

Websitehttps://www.rrkchem.com

Fan De(Beijing) Biotechnology Co., Ltd.

Telephone 15911056312

Websitehttp://www.bio-fount.com/

Hefei Molake Biotechnology Co., Ltd.

Telephone0551-66336380 18956014586

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList31079/0_EN.htm

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Telephonemeitaochem@126.com

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList31244/0_EN.htm

1of4

Related Products

Send Inquriy