145301-48-0

Name	BIBN 99
CAS	145301-48-0
Molecular Formula	C31H42ClN5O3
MDL Number	MFCD00867672
Molecular Weight	568.15
MOL File	145301-48-0.mol

Synonyms

BIBN 99 N-[3-[1-[2-(8-chloro-6-oxo-5~{H}-pyrido[2,3-b][1,4]benzodiazepin-11-yl)-2-oxoethyl]piperidin-4-yl]propyl]-N-ethyl-2,2-dimethylpentanamide Pentanamide, N-[3-[1-[2-(8-chloro-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepin-11-yl)-2-oxoethyl]-4-piperidinyl]propyl]-N-ethyl-2,2-dimethyl-

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Description

Bibn 99 is a lipophilic and selective muscarinic M2 receptor antagonist with applications to cognitive performance and Alzheimer's Disease.

Uses

BIBN-99 is a selective, BBB-penetrable and competitive muscarinic M2 receptor antagonist. BIBN-99 improves cognitive performancein rats with traumatic brain injury[1][2].

References

[1] Doods H, et al. Characterization of BIBN 99: a lipophilic and selective muscarinic M2 receptor antagonist. Eur J Pharmacol. 1993 Sep 21;242(1):23-30. DOI:10.1016/0014-2999(93)90005-3
[2] Pike BR, et al. Post-injury administration of BIBN 99, a selective muscarinic M2 receptor antagonist, improves cognitive performance following traumatic brain injury in rats. Brain Res. 1995 Jul 17;686(1):37-43. DOI:10.1016/0006-8993(95)00448-y

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Websitehttps://www.targetmol.cn/

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