Hazard Information
Description
Ald-CH2-PEG5-t-butyl ester is an aldehyde PEG linker that is reactive with aminooxy-containing molecules. The t-butyl ester can be removed under acidic conditions for further conjugation.PEG5 spacer of the compound arimproves aqueous solubility.
Uses
Ald-CH2-PEG5-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034. DOI:10.1021/acschembio.9b00505
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