143488-32-8

Ro 25-0534 is antimicrobial activity of a new antipseudomonal dual-action drug.

Ro 25-0534 is an antimicrobial compound against Pseudomonas. Ro 25-0534 is active against Enterobacteriaceae (MIC90: 0.06-2 μg/mL), Oxacillin (HY-B0465)-susceptible staphylococci, β-hemolytic streptococci, and penicillin-susceptible pneumococci (MIC90: 1-2 μg/mL), Haemophilus influenzae (MIC90: 0.25-0.5 μg/mL), Moraxella catarrhalis (MIC90: 0.5 μg/mL), and most nonenteric Gram-negative bacilli (MIC90: 2-4 μg/mL)[1].

[1] Jones RN, et al. Antimicrobial activity of a new antipseudomonal dual-action drug, Ro 25-0534. Diagn Microbiol Infect Dis. 1994 Jan;18(1):61-8. DOI:10.1016/0732-8893(94)90135-x