143248-63-9

Name	Sinitrodil
CAS	143248-63-9
Molecular Formula	C10H10N2O5
MDL Number	MFCD00864675
Molecular Weight	238.198
MOL File	143248-63-9.mol

Synonyms

ITF296 ITF-296 ITF 296 Sinitrodil

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Hazard Information

Uses

Sinitrodil (ITF 296) is an orally active organic nitrate with anti-ischaemic effect. Sinitrodil can be used for acute and chronic heart diseases research[1][2].

in vivo

1.19
Pharmacokinetic parameters of Sinitrodil in rats^[2]

Route	Parameter	Value
IV (1 mg/kg)	CL (L/h/kg)	2.7
	AUC (μg h/mL)	0.37
	T_1/2 (h)	3.85
PO (5 mg/kg)	T_max (h)	0.17
	T_1/2 (h)	1.95
	C_max (μg/mL)	2.099
	CL (L/h/kg)	2.69
	AUC (μg h/mL)	1.364

References

[1] Monzani MV, et al. Pharmacokinetics of ITF 296 (Sinitrodil) a novel organic nitrate, in healthy volunteers. Eur J Pharm Sci. 1999 Feb;7(3):179-84. DOI:10.1016/s0928-0987(98)00026-8
[2] Monzani MV, et al. Pharmacokinetic Profile of ITF 296 in Rats and Dogs. Journal of Cardiovascular Pharmacology 26:p S67-71,

Spectrum Detail

Sinitrodil(143248-63-9)¹HNMR

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