1429024-58-7

STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a Ki value of 0.16 μM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1[1].

[1] Murray MH, et al. Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB. Nat Commun. 2022 Nov 21;13(1):7131. DOI:10.1038/s41467-022-34892-4