Description
JWH 081 is a synthetic cannabinoid (CB) that shows a high-
affinity for the central CB
1 receptor with a K
i value of 1.2 nM and ten-
fold reduced affinity for the peripheral CB
2 receptor (K
i = 12.4 nM).
1,2 JWH 081 5-
methoxynaphthyl isomer differs structurally from JWH 081 by having the methoxy group attached to the naphthyl rings at the 5 position, instead of the 4 position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.
References
1. Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding Drug Alcohol Depend. 60(2),133-140(2000).
2. Huffman, J.W., Zengin, G., Wu, M.J., et al. Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: Steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists Bioorg. Med. Chem. 13(1),89-112(2005).
