1421933-29-0

Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a branched PEGylation compound with a terminal azide group and three t-butyl groups. The t-butyl groups can be removed under acidic conditions. The azide group can participate in copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN to form stable triazole linkages. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media.

Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4-Amido-tri-(t-butoxycarbonylethoxymethyl)-methane is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

PEGs

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005