ChemicalBook CAS DataBase List 1421693-22-2

1421693-22-2

Name	CDKI-73
CAS	1421693-22-2
Molecular Formula	C15H15FN6O2S2
MDL Number	MFCD28386217
Molecular Weight	394.45
MOL File	1421693-22-2.mol

Chemical Properties

Boiling point	642.9±65.0 °C(Predicted)
density	1.524±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:52.0(Max Conc. mg/mL);131.83(Max Conc. mM)
form	Solid
pka	10.06±0.60(Predicted)
color	Light yellow to yellow

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Animal Model:	MV4-11 tumor bearing mice^[3].
Dosage:	25 mg/kg.
Administration:	Orally once everyday for 33 days.
Result:	Caused a remarkable delay in tumor growth compared to vehicle-treated mice, as reflected in a percentage for the mean tumor volume in treated to control mice of 43% at day 31.

Animal Model:	Balb/C mice aged 6-8 weeks^[3].
Dosage:	2 mg/kg (IV), 10, 20 and 40 mg/kg (PO). (Pharmacokinetic Analysis.)
Administration:	IV and PO, single dose.
Result:	The C_max increased from 1.29 to 3.66 μM at a mean time of 1 h and the area under the curve (AUC) of CDKI-73 increased from 3.51 to 12.8 μM.h when the oral dose was escalated from 10 to 40 mg/kg. CDKI-73 was eliminated from plasma with a mean terminal half-life (T1/2) of 2 h. Its oral bioavailability (F) ranged from 54 to 85% across the three doses.

1421693-22-2

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in vivo

IC 50

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