Originator
A-Spasm ,Acme Laboratories Ltd.
Definition
ChEBI: 2-(2-cyclohexyl-2-hydroxy-1-oxo-2-phenylethoxy)ethyl-diethyl-methylammonium is an acylcholine.
Manufacturing Process
1 mol cycloxehylhydroxyphenylacetic acid methyl ester was mixed with 1 mol 2-diethylaminoethanol in presence of 1 mol sodium methylate to give cycloxehylhydroxyphenylacetic acid 2-diethylamino-ethyl ester.
5 parts by weight of it was dissolved in 50 volumes glacial acetic acid and a gaseous methyl bromide was introduced. The mixture was heated to about 50°C and crystallization of cycloxehylhydroxyphenylacetic acid diethylaminoethyl ester methyl bromide has shortly after begun. On cooling the crystals was filtered off and recrystallized from mixture of ethyl acetate ant a little ethanol to give the oxyphenonium bromide. MP: 189°-191°C.
Brand name
Antrenyl (Novartis).
Therapeutic Function
Anticholinergic, Spasmolytic
