1418293-40-9

NT160 is a highly potent class-IIa HDAC inhibitor with an IC50 value of 0.046 μM. NT160 can be used for the research of central nervous system diseases[1].

HDAC4: 0.08 nM (IC₅₀); HDAC5: 1.2 nM (IC₅₀); HDAC7: 1.0 nM (IC₅₀); HDAC9: 0.9 nM (IC₅₀)

[1] Turkman N, et al. Design, synthesis, biochemical evaluation, radiolabeling and in vivo imaging with high affinity class-IIa histone deacetylase inhibitor for molecular imaging and targeted therapy. Eur J Med Chem. 2022;228:114011. DOI:10.1016/j.ejmech.2021.114011