141543-63-7

Pale Yellow Solid

Exhibited potent inhibition toward protein kinase C and cyclic nucleotide dependent protein kinases.

Exhibited potent inhibition toward protein kinase C and cyclic nucleotide dependent protein kinases.

PKG: 4 μM (IC₅₀); PKA: 8 μM (IC₅₀); PKC: 12 μM (IC₅₀); MLCK: 240 μM (IC₅₀); ROCK

[1] Hagiwara M, et, al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12. PMID:2955213
[2] Yu J, et, al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6(3):e17557. DOI:10.1371/journal.pone.0017557