1415050-59-7

GP29 is a Type II kinase inhibitor of the IRE1α endoribonuclease. It acts by targeting the ATP-binding pocket of IRE1α.

IRE1α kinase-IN-10 (GP29) is an IRE1α kinase inhibitor. IRE1α kinase-IN-10 can be used for the research of endoplasmic reticulum stress-related diseases[1].

[1] Wang L, et al. Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nat Chem Biol. 2012 Dec;8(12):982-9. DOI:10.1038/nchembio.1094