1415030-15-7

Name	APX2009
CAS	1415030-15-7
Molecular Formula	C21H25NO4
Molecular Weight	355.43
MOL File	1415030-15-7.mol

Synonyms

APX2009 Pentanamide, 2-[(1,4-dihydro-3-methoxy-1,4-dioxo-2-naphthalenyl)methylene]-N,N-diethyl-

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Chemical Properties

Boiling point	514.8±50.0 °C(Predicted)
density	1.16±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 10mg/mL, clear
form	powder
pka	-1.03±0.70(Predicted)
color	white to beige

Hazard Information

Uses

APX2009 is a specific APE1/REF-1 redox inhibitor with anticancer activities which decreases the proliferative, migratory, and invasive properties of breast cancer cell and induces apoptosis in breast cancer cell[1].

Biological Activity

APX2009 is a cell penetrant potent and selective second-generation inhibitor of APE1 redox-signaling th at stimulates APE1 DNA repair activity. APX2009 is neuroprotective against cisplatin and oxaliplatin induced toxicity. APX2009 exhibits potent antitumor activity in neuroblastoma cell lines and 3D spheroid pancreatic tumor model.

References

[1] Siqueira PB, et al. The inhibitor of the redox activity of APE1/REF-1, APX2009, reduces the malignant phenotype of breast cancer cells. Braz J Med Biol Res. 2024 May 20;57:e13250. DOI:10.1590/1414-431X2024e13250

Supplier

Shanghai Beckham Medical Technology Co., Ltd

Telephone021-13816613772 13816613772

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList16976/0.htm

Nantong QuanYi Biotechnology Co., Ltd

Telephone0513-66337626 18051384581

Websitehttps://www.chemhifuture.com/

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Merck KGaA

Telephone21-20338288

Websitehttp://www.sigmaaldrich.cn

Selleck Chemicals

Telephone400-668-6834

Websitehttp://www.selleckchem.com

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