140111-52-0

(+)-Epibatidine has binding affinities for α4β2 and α3β4 nicotinic receptors.

[1] Simon C. Clayton,Andrew C. Regan. A total synthesis of (±)-epibatidine. Tetrahedron Letters. Volume 34, Issue 46, 12 November 1993, Pages 7493-7496.

Very potent nicotinic agonist (K i values are 0.02 and 233 nM for α 4 β 2 and α 7 nicotinic receptors respectively). Analgesic.

Andrew C. Regan and colleagues reported a total synthesis of the potent non-opiate analgesic alkaloid epibatidine is described, in which the key step is a reductive palladium-catalysed Heck-type coupling.[1]  (±)-Epibatidine has being synthesised, employing a reductive palladium-catalysed coupling as the key reaction.