Elismetrep (MT-8554) is an oral active TRPM8 inhibitor, and can be used for study of analgesic[1][2].
References
[1] Conklin M, et al. Neurokinin receptor antagonists as potential non-hormonal treatments for vasomotor symptoms of menopause. Ther Adv Reprod Health. 2023 Jun 22;17:26334941231177611. DOI:10.1177/26334941231177611 [2] Weyer AD, et al. Development of TRPM8 Antagonists to Treat Chronic Pain and Migraine. Pharmaceuticals (Basel). 2017 Mar 30;10(2):37. DOI:10.3390/ph10020037
