Actinorhodin is a benzoisochromanequinone polyketide antibiotic produced from Streptomyces coelicolor (Magnolo et al. 1991). It belongs to a class of aromatic polyketides synthesized by type II PKSs (Manikprabhu and Lingappa 2013). It can be used as a pH indicator, turning red below pH 8.5 and blue above.
Uses
Actinorhodin is a blue-pigmented, redox-active microbial secondary metabolite. Actinorhodin is a potent, bacteriostatic, pH-responsive antibiotic. Actinorhodin exhibits antimicrobial activity against Gram-positive bacteria[1].
Definition
ChEBI: Actinorhodin is a member of the class of benzoisochromanequinone that is produced by Streptomyces coelicolor A3(2) and exhibits antibiotic activity. It has a role as a bacterial metabolite and an antimicrobial agent. It is a benzoisochromanequinone, a polyketide, a dicarboxylic acid, a polyphenol, a ring assembly and a member of p-quinones. It is a conjugate acid of an actinorhodin(3-).
References
[1] Mak S, et al. Actinorhodin is a redox-active antibiotic with a complex mode of action against Gram-positive cells. Mol Microbiol. 2017 Nov;106(4):597-613. DOI:10.1111/mmi.13837
