13947-21-2

HLE-IN-1 (Compound 4) is a human leukocyte elastase HLE inhibitor (Ki=1.8 nM). HLE-IN-1 is used in emphysema and inflammamry pulmonary research[1].

[1] Hlasta, et al. A benzisothiazolone class of potent, selective mechanism-based inhibitors of human leukocyte elastase. Bioorganic & Medicinal Chemistry Letters, 4(15), 1801–1806.