1391452-80-4

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Sirtuin 6 (Sir6) is a mono-ADP-ribosyltransferasewhich catalyzes the transfer of ADP-ribose moiety from NAD to itself and histones. It has been implicated in the regulation of DNA repairgenomic stability and telomere integritygene expressionand metabolism. In additionit also prevents age-related disorders and premature aging. Sir6 plays a vital role in the inhibition of nuclear factor-KB (NF-KB)–mediated inflammatory responses in rheumatoid joints. HenceSir6 is considered to be a potent target for treatment of rheumatoid arthritis (RA). Sir6 is also majorly implicated in the regulation of glucose and f at metabolism. Sir6 prevent cardiac hypertrophy in vitro via inhibiting NF-KB-dependent transcriptional activity and this effect is relied on its deacetylase activity.