1383420-08-3

Rencofilstat (CRV431) is a pan-cyclophilin inhibitor with IC50 values of 2.5 nM, 3.1 nM, 2.8 nM, 7.3 nM for Cyp A, CypB, Cyp D and Cyp G, respectively. Rencofilstat reduces fibrosis and tumor growth in models of chronic liver disease[1].

Cyclophilin A: 2.5 nM (IC₅₀); Cyclophilin B: 3.1 nM (IC₅₀); Cyclophilin D: 2.8 nM (IC₅₀); Cyclophilin G: 7.3 nM (IC₅₀)

[1] Joseph Kuo, et al. A Pan-Cyclophilin Inhibitor, CRV431, Decreases Fibrosis and Tumor Development in Chronic Liver Disease Models. J Pharmacol Exp Ther. 2019 Nov;371(2):231-241.