TIQ-15 is a potent and selective CXCR4 antagonist with good drug-like properties.
Uses
TIQ-15 is a potent CXCR4 antagonist with an IC50 value of 6 nM for CXCR4 Ca2+ flux. TIQ-15 inhibits CYP450 2D6 with an IC50 value of 0.32 μM[1].
IC 50
CXCR4: 6 nM (IC50)
References
[1] Tahirovic YA, et, al. Discovery of N-Alkyl Piperazine Side Chain Based CXCR4 Antagonists with Improved Drug-like Properties. ACS Med Chem Lett. 2018 Apr 9;9(5):446-451. DOI:10.1021/acsmedchemlett.8b00030
