1379604-70-2

JWH 019 is a cannabimimetic indole that shows a high-affinity for both the central cannabinoid (CB) and the peripheral CB receptors.¹ It has been detected in certain herbal blends sold for human consumption. JWH 019 5-hydroxyindole metabolite is expected to be a major metabolite of JWH 019, detectable in serum and urine.^2,3 The biological effects of the metabolite are not known

1. Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB₁ and CB₂ receptor binding Drug Alcohol Depend. 60(2),133-140(2000).
2. Sobolevsky, T., Prasolov, I., and Rodchenkov, G. Detection of JWH-018 metabolites in smoking mixture post-administration urine Forensic Sci. Int. 200(1-3),141-147(2010).
3. Zhang, Q., Ma, P., Cole, R.B., et al. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB₂) by HPLC-MS/MS Anal. Bioanal. Chem. 386(5),1345-1355(2006).