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FAK-IN-8 (compound 5h) is a FAK inhibitor (IC50=5.32 μM). FAK-IN-8 has good anti-proliferative activity and can be used in cancer research[1].

FAK: 5.32 μM (IC₅₀)

[1] Yang XH, et al. Synthesis, biological evaluation, and molecular docking studies of 1,3,4-thiadiazol-2-amide derivatives as novel anticancer agents. Bioorg Med Chem. 2012 May 1;20(9):2789-95. DOI:10.1016/j.bmc.2012.03.040