1374107-46-6

THK-5105, an arylquinoline derivative, displays high binding affinity to tau fibrils. THK-5105 has high binding affinity to tau protein aggregates and tau-rich Alzheimer disease (AD)? brain homogenates. 18F-THK-5105 has?the?potential to act as a tau imaging PET probe[1].

[1] Nobuyuki Okamura, et al. Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease. J Nucl Med. 2013 Aug;54(8):1420-7. DOI:10.2967/jnumed.112.117341