137348-11-9

Substance P acetate salt hydrate has been:

• used as a neurokinin 1 (NK1) receptor agonist for the activation of spinal nociceptive circuitry in mice
• administered in central nucleus (ACE) in rat to study its positive reinforcing effects
• used as an inhibitor of myosin light chain kinase in isolated lymphatic vessels from rat

Substance P is a small peptide produced by macrophages, lymphocytes, eosinophils, dendritic cells and nerves. It is part of the neurokinin group.

NK-1 agonist; potent vasodilator and hypotensive agent; induces salivation; increases capillary permeability; induces mast cell degranulation; putative neurotransmitter in sensory (pain) afferents.