137018-54-3

Okicenone is an antibiotic, interferring with HuR RNA binding, HuR trafficking, cytokine expression and T-cell activation.

Okicenone is a Hu protein R (HuR) inhibitor. Okicenone inhibits HuR oligomerization, interferes with HuR RNA binding, HuR trafficking, cytokine expression and T-cell activation[1].

[1] Meisner NC, et al. Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR. Nat Chem Biol. 2007 Aug;3(8):508-15. DOI:10.1038/nchembio.2007.14