136941-85-0

Name	PCA 50941
CAS	136941-85-0
Molecular Formula	C30H31N3O10S
MDL Number	MFCD00905723
Molecular Weight	625.65
MOL File	136941-85-0.mol

Synonyms

PCA 50941 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)ethyl] 5-[(tetrahydro-2H-pyran-2-yl)methyl] ester

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Chemical Properties

Boiling point	816.6±75.0 °C(Predicted)
density	1.387±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
pka	2.60±0.70(Predicted)

Hazard Information

Uses

PCA50941 is a 1,4-dihydropyridine derivative, used for treatment for cardiovascular disease.

in vivo

PCA50941 (10-120 μM) by intracoronary injection, causes smaller reductions of coronary blood flow (CBF) in goats. PCA50941 (10-300 μM/min) does not modify CBF nor the other hemodynamic variables recorded by i.v. infusions in 4 goats. Intravenous infusion of PCA50941 (100 microg/min) reverses the hemodynamic variables from the shock state to control values within 20 min in 5 of 6 animals^[2].

References

[1] Montiel C, et al. Interactions between Ca2+, PCA50941 and Bay K 8644 in bovine chromaffin cells. Eur J Pharmacol. 1994 Aug 16;268(3):293-303. DOI:10.1016/0922-4106(94)90053-1
[2] Fernández N, et al. PCA50941, a new 1,4-dihydropyridine, reverses endothelin-induced cardiogenic shock in the anesthetized goat. Life Sci. 1998;62(21):1933-42. DOI:10.1016/s0024-3205(98)00162-3

Supplier

Beijing Jin Ming Biotechnology Co., Ltd.

Telephone010-60605840 15801484223;

Websitehttp://www.jm-bio.com/

TargetMol Chemicals Inc.

Telephone 4008200310

Websitehttps://www.targetmol.cn/

Biosynth Biological Technology (Suzhou) Co Ltd

Telephone 51288865780

Websitehttp://www.biosynth.com

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