1368310-81-9

The general procedure for the synthesis of 2-(methylamino)-1H-benzo[d]imidazole-5-carboxylic acid, using the compound (CAS:1374258-49-7) as starting material, was as follows: to methyl 2-(methylamino)-1H-benzo[d]imidazole-5-carboxylate (2.9 g, 14 mmol) was added an aqueous solution of 3N hydrochloric acid (14 mL, 42 mmol), the reaction mixture was stirred under reflux conditions overnight. After completion of the reaction, the reaction solution was concentrated to afford 2-(methylamino)-1H-benzo[d]imidazole-5-carboxylic acid (2.4 g, 90% yield), the product was a yellow solid.1H NMR (400 MHz, CD3OD, δ): 7.96-8.00 (m, 2H), 7.40 (d, J = 8.4 Hz, 1H), 3.10 (s, 3H).

[1] Patent: US2012/108619, 2012, A1. Location in patent: Page/Page column 39
[2] Patent: US2012/270893, 2012, A1. Location in patent: Page/Page column 29