136286-49-2

WS 009A is an endothelin receptor antagonist; from Streptomyces sp. No. 89009.

WS009A is an antagonist for endothelin receptor (ET Receptor) with IC50 of 5.8 and 6.9 μM for ET-1 receptor and ET-2 receptor. WS009A can be used in research of cardiovascular diseases[1].

[1] Miyata S, et al., WS009 A and B, new endothelin receptor antagonists isolated from Streptomyces sp. no. 89009. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1992 Jul;45(7):1029-40. DOI:10.7164/antibiotics.45.1029