1354037-26-5

KH-CB19 is a potent CLK (cdc2-like kinase) inhibitor (CLK1 IC50=19.7 nM; CLK3 IC50=530 nM). KH-CB19 shows antiviral activity and inhibits influenza virus replication (IC50=13.6?μM)[1][2].

CLK1: 19.7 nM (IC₅₀); CLK3: 530 nM (IC₅₀); DYRK1A: 55.2 nM (IC₅₀)

[1] Fedorov O, et al. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011 Jan 28;18(1):67-76. DOI:10.1016/j.chembiol.2010.11.009
[2] Artarini A, et al. Regulation of influenza A virus mRNA splicing by CLK1. Antiviral Res. 2019 Aug;168:187-196. DOI:10.1016/j.antiviral.2019.06.003