135139-00-3

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Questions And Answer

• Synthesis

  Synthesis of 135139-00-3

  Using phosphorus tribromide as a starting material, bis(3,5-dimethylphenyl)phosphine oxide was reacted with bis(3,5-dimethylphenyl)phosphine to obtain bis(3,5-dimethylphenyl)phosphine in 92% yield. Then, coupling was performed under Ni(dppe)Cl₂ as a catalyst and zinc powder as a reducing agent to yield (S)-(-)-2,2'-Bis[di(3,5-xylyl)phosphino]-1,1'-binaphthyl.

  

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• Reaction

  1. Ligand used in copper-catalyzed asymmetric Mannich-type reactions of N-acylimino esters.
  2. Ligand used in the enantioselective fluorination of oxindoles.
  3. Ligand used in [2+2+2] cycloaddition of tetraynes and hexaynes.
  4. Ligand used in the asymmetric reduction of ketone via ruthenium-catalyzed transfer hydrogenation.
  5. Asymmetric hydroboration of unsaturated imines.
      
  
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Spectrum Detail

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