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Aciculatin, a natural compound extracted from the medicinal herb Chrysopogon aciculatus, shows potent anti-cancer potency. Aciculatin treatment induces cell cycle arrest and apoptosis via inhibition of MDM2 expression, thereby inducing p53 accumulation without significant DNA damage and genome toxicity.

Aciculatin is a compound with cytotoxic, anti-inflammatory and anti-arthritic activities, and its synthetic route including specific chemical reaction steps was determined through the first total synthesis.

ChEBI: Aciculatin is a member of flavonoids and a C-glycosyl compound.

[1] Total Synthesis of the Naturally Occurring Glycosylflavone Aciculatin DOI:10.1021/acs.jnatprod.5b01051