133825-81-7

Nevanimibe Hydrochloride can be used for combinatory treatment strategies of cancer based on RNA polymerase I inhibition.

ATR-101 (PD 132301-02; Nevanimibe HCl) is an orally activepotent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT1SOAT1) inhibtior (IC50 = 52 nM; intestinal microsome from cholesterol-fed rabbits) th at reduces plasma cholesterol in both acute (by 77%; 50 mg/kg po.) and chronic (by 80%; 10 mg/kg po.) cholesterol-fed r at models. In additionATR-101 is reported to exhibit therapeutic efficacy against adrenocortical carcinoma (ACC)congenital adrenal hyperplasia (CAH)and Cushingμs syndrome (CS).

ACAT1: 9 nM (EC₅₀); ACAT2: 368 nM (EC₅₀)