132971-59-6

Cytogenin is a microbial product that was found to be an orally active antitumor agent against murine tumors.

Cytogenin (Antibiotic MI 43-37F11) is an orally active antineoplastic antibiotic. Cytogenin regulates the inflammatory cytokine, reduces the levels of iNOS, NO and IL-6 in mouse macrophages, and exhibits antidiabetic efficacy in mice. Cytogenin inhibits growth of Ehrlich ascites tumor in mouse model[1][2][3].

[1] Kumagai H, et al., Biosynthesis of antitumor antibiotic, cytogenin. J Antibiot (Tokyo). 1994 Apr;47(4):440-6. DOI:10.7164/antibiotics.47.440
[2] Kumagai H, et al., Cytogenin, a novel antitumor substance. J Antibiot (Tokyo). 1990 Nov;43(11):1505-7. DOI:10.7164/antibiotics.43.1505
[3] Kumagai H, et al., Effect of cytogenin, a novel immunomodulator, on streptozotocin-induced diabetes in mice. J Antibiot (Tokyo). 2005 Mar;58(3):202-5. DOI:10.1038/ja.2005.24