132928-46-2

PF 10040 is a platelet activating factor (PAF) antagonist.

PF-10040 is a quinoline derivative that can inhibit PAF-induced airway hyperresponsiveness. PF-10040 also shows protective effect in experimental NSAID-gastritis[1][2].

[1] Herd CM, et, al. Effect of PF 10040 on PAF-induced airway responses in neonatally immunized rabbits. Br J Pharmacol. 1994 Jan;111(1):7-12. DOI:10.1111/j.1476-5381.1994.tb14016.x
[2] Wallace JL, et, al. Protective effects of PF-10040 in experimental NSAID-gastritis: role of leukocytes, leukotrienes and PAF. J Lipid Mediat. 1993 Jun;7(2):183-96. PMID:8400119