132417-97-1

BE-12406B is an antitumor agent that can be found in the culture broth of a streptomycete. BE-12406B can inhibit the growth of Vincristine (HY-N0488)-resistant or Doxorubicin (HY-15142A)-resistant P388 murine leukemia cell lines as well as their parent sensitive cell line[1][2].

[1] Nakajima S, et, al. New antitumor substances, BE-12406A and BE-12406B, produced by a streptomycete. II. Structure determination. J Antibiot (Tokyo). 1991 Oct;44(10):1061-4. DOI:10.7164/antibiotics.44.1061
[2] Kojiri K, et, al. New antitumor substances, BE-12406A and BE-12406B, produced by a streptomycete. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties. J Antibiot (Tokyo). 1991 Oct;44(10):1054-60. DOI:10.7164/antibiotics.44.1054