ChemicalBook CAS DataBase List 131602-53-4

131602-53-4

Name	AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE
CAS	131602-53-4
Molecular Formula	C45H81N13O14S
MDL Number	MFCD04113709
Molecular Weight	1060.27
MOL File	131602-53-4.mol

Chemical Properties

Boiling point	1517.3±65.0 °C(Predicted)
density	1.248±0.06 g/cm3(Predicted)
RTECS	BU7435200
storage temp.	-20°C
solubility	insoluble in EtOH; insoluble in H2O; ≥106 mg/mL in DMSO
form	Lyophilized.
pka	3.24±0.10(Predicted)
color	Lyophilized White
Water Solubility	Soluble in water.
Sequence	H-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH
InChIKey	WIHBNMPFWRHGDF-SLVFWPMISA-N

Safety Data

WGK Germany	3
HS Code	2930909899

Hazard Information

Description

Beta-amyloid protein (Abeta), a major component of senile plaques of Alzheimer's disease (AD) in the brain, causes elevation of the intracellular free Ca2+ level and the production of robust free radicals. Beta-amyloid 25-35 induced apoptosis, characterized by decreased cell viability, neuronal DNA condensation, and fragmentation, is associated with an increase in intracellular free Ca2+ level, the accumulation of reactive oxygen species (ROS), and the activation of caspase-3. All of these effects induced by beta-amyloid 25-35 are reversed by genistein.

Uses

Amyloid β-Protein Fragment 25-35 has been used:

to induce neurotoxicity in cortical cultures
to induce Alzheimer′s disease in rat model
to induce apoptosis in mesenchymal stem cells (MSCs)

General Description

Amyloid β-Protein Fragment 25-35 (Aβ25-35) is derived from the amyloid-β protein.amyloid-β protein, which is mapped to human chromosome 21q21. Aβ25-35 lacks the N-terminal domain and the metal binding site and is majorly generated by proteolytic cleavage of Aβ(1?40) peptides. It has a β-sheet and β-turn structure.

Biological Activity

Amyloid β-peptide (25-35) (human) is a fragment of human amyloid β-peptide, functionally required for the neurotrophic and neurotoxic effects associated with Alzheimer's disease.

Biochem/physiol Actions

Amyloid β-Protein Fragment 25-35 (Aβ25-35) is involved in the pathogenesis of Alzheimer′s disease. Inhibitors of this transition may serve as a potential agent in managing Alzheimer′s disease. It is present in the subiculum and entorhinal cortex neurons of Alzheimer′s brain samples and inclusion-body myositis (IBM) muscle. It binds to receptors present in microglia and is capable of lipid membrane insertion. The functional domain sequence of Aβ comprising of sequence GSNKGAIIGLM elicits neurotrophic and neurotoxic effects. Aβ25-35 exhibits rapid aggregation and displays age dependant neurotoxicity.

Mechanism of action

Amyloid β (Aβ) peptide is a proven major contributing component of neuritic plaques of Alzheimer's disease (AD) . The formation of fibrillar deposits of Aβ peptide in brain is a key step in the pathogenesis of this disease, since the conversion of Aβ from soluble monomer to insoluble fibril is considered to cause the neuronal degeneration and clinical dementia in AD patients. Recent biophysical studies such as electron microscopy, solid-state NMR, Fourier transform infrared (FTIR), and electronic circular dichroism (ECD) spectra indicated that the Aβ fibrils exhibit a high β-sheet content. The conversion of normal Aβ peptides with water-soluble α-helical/random coil structures into the insoluble Aβ aggregates with an extensive β-sheet content is considered to be the predominant event in the onset of AD.

storage

-20°C

Spectrum Detail

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