1313392-39-0

162607-17-2

1313392-39-0

The general procedure for the synthesis of 2-hydroxy-5-bromothiophene from 5-bromothiophene-2-boronic acid was as follows: in a 25 mL reaction flask, pentafluorophenylhydrazine (0.35 mmol), 5-bromothiophene-2-boronic acid (0.5 mmol), 1,8-diazabicyclo[5.4.0]undec-7-ene (1.0 mmol), water (1.5 mmol) and polyethylene glycol-600 (2.0 g). The mixture was stirred at 80 °C until the reaction was complete (monitored by TLC). Upon completion of the reaction, the reaction mixture was cooled to room temperature, followed by evaporation under reduced pressure to remove the solvent. Finally, the crude product was purified by column chromatography to afford the target compound 2-hydroxy-5-bromothiophene in 79% yield.