MK-8457 is a dual SYK/ZAP70 inhibitor. MK-8457 can be used for research of rheumatoid arthritis[1].
References
[1] Coffey G, et al. PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers. J Clin Pharmacol. 2017 Feb;57(2):194-210. DOI:10.1002/jcph.794