13072-89-4

4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Na_v1.6 voltage-activated sodium channels (IC₅₀ = 7.8 nM in Xenopus oocytes). It demonstrates IC₅₀ values of 1.3, 0.34, 0.99, 78.5, 1.3, and >30 μM for Na_v1.2, Na_v1.3, Na_v1.4, Na_v1.5, Na_v1.7, and Na_v1.8, respectively.

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1) Rosker?et al. (2007),?The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Na(v1.6) voltage-dependent sodium channel; Am.J.Physiol.Cell Physiol.,?293?C783. 2) Denomme?et al.?(2020),??The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6;?Neurosci. Lett.?724?134853