129184-48-1

Name	Y-29794 OXALATE
CAS	129184-48-1
Molecular Formula	C23H34N2OS2
MDL Number	MFCD06411588
Molecular Weight	418.66
MOL File	129184-48-1.mol

Synonyms

Y 29794 Y-29794 OXALATE [2-(8-Dimethylamino-octylsulfanyl)-6-isopropyl-pyridin-3-yl]-thiophen-2-yl-methanone Methanone, [2-[[8-(dimethylamino)octyl]thio]-6-(1-methylethyl)-3-pyridinyl]-2-thienyl- [2-[[8-(DIMETHYLAMINO)OCTYL]THIO]-6-(1-METHYLETHYL)-3-PYRIDINYL]-2-THIENYLMETHANONE OXALATE

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Chemical Properties

storage temp.

Desiccate at +4°C

Hazard Information

Uses

Y-29794 Oxalate was used in a biological study of nerve growth factor formation enhancement.

Biological Activity

Inhibitor of prolyl endopeptidase, a serine peptidase that may be implicated in the biosynthesis of amyloid β -peptide. Potently inhibits rat brain prolyl endopeptidase (K i = 0.95 nM) in vitro , and prevents amyloid β -peptide deposition in vivo . Orally active and brain penetrant.

in vivo

Y-29794 (12.5-50 mg/kg, i.p. daily, 5 times a week for 5 weeks) exhibits antitumor efficacy against triple-negative breast cancer in NOD-SCID mice models, without significant toxicity^[1].

Animal Model:	TNBC xenograft NOD-SCID mice model^[1]
Dosage:	12.5-50 mg/kg
Administration:	i.p., daily, 5 times a week for 5 weeks
Result:	Inhibited tumor growth, maintained body weight.

IC 50

PREP: 3 nM (IC₅₀)

Supplier

3B Pharmachem (Wuhan) International Co.,Ltd.

Telephone 18930552037

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList13285/0_EN.htm

Santa Cruz Biotechnology Inc

Telephone021-60936350

Websitehttp://www.scbt.com

Hangzhou MolCore BioPharmatech Co.,Ltd.

Telephone+86-057181025280; +8617767106207

Websitehttps://www.molcore.com/

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