127975-78-4

FR 75513 has inhibitory activity on guinea pig detrusor muscle contraction.

FR 75513 is a 1,1'-biphenyl-2,6-dicarboxylic acid diester series compound that can inhibit the contraction of the detrusor muscle of guinea pig bladder (IC50=3.3 μg/mL). After intravenous injection of FR 75513 into anesthetized rats, it also showed strong inhibitory activity on the detrusor contraction (ID50=0.04 mg/kg).

[1] Agents for the Treatment of Overactive Detrusor. I. Synthesis and Structure-Activity Relationships of 1, 1'-Biphenyl Derivatives